李先輝，男，1976年5月生，湖北當陽人，中共黨員，華中科技大學藥理學博士，教授，碩士研究生導師，湖南省芙蓉青年學者，湖南省青年骨幹教師，77779193永利第三屆“青年科技之星”，湖南省檢驗教育專業委員會專業委員，湘西自治州藥學會副主任委員、常務理事，Neurochemistry International、Neurotoxicity Research、Pharmaceutical Biology等期刊特約審稿人。主持國家自然科學基金課題4項，教育廳重點項目1項，一般項目1項，主持國家民委等教改項目4項；獲省級科技成果進步獎三等獎1項，校級教學成果二等獎2項，發表SCI論文20餘篇，主編參編教材3部，專著1部。
聯系方式：Email:lxhsurgeon@163.com; Tel: 18707439733
【研究領域】
1.神經退行性和代謝性疾病藥物靶點的确定及藥效學評價
2.民族藥物網絡藥理學機制研究
【主持的主要科研項目】
1.國家自然科學基金地區基金項目.NO. 81260489.内質網應激PERK 信号通路
與阿爾茨海默病的關系及大蒜素的保護作用研究.2012-2014
2.國家自然科學基金地區基金項目.NO. 81460547.Cdk5介導的AMPKα2蛋白磷
酸化在糖尿病腦病中的作用機制研究.2014-2018
3.國家自然科學基金地區基金項目.NO. 81660598.海馬Fndc5基因啟動子區組蛋
白甲基化修飾在糖尿病腦損傷中的作用.2016-2020
4.國家自然科學基金地區基金項目.NO. 81860636LncRNA NONRATG022419調控
PRG-1的表達在糖尿病腦損傷中的作用及機制研究.2018-2022
5.湖南省教育廳重點項目.NO.14A117主持Cdk5介導的AMPK蛋白磷酸化在糖尿
病腦損傷中的作用機制研究.2014-2018
窗體頂端
【主要學術論文】
1.Yan Li , Qiong Xiang , Yu-Han Yao , Jing-Jing Li , Yan Wang , Xian-Hui Li （通訊）.Inactivated AMPK-α2 promotes the progression of diabetic brain damage by Cdk5 phosphorylation at Thr485 site.Biochimie. 2020 Jan;168:277-284
2.Qiong Xiang , Jing-Jing Li , Chun-Yan Li , Rong-Bo Tian ,Xian-Hui Li（通訊）Somatostatin Type 2 Receptor Antibody Enhances Mechanical Hyperalgesia in the Dorsal Root Ganglion Neurons after Sciatic Nerve-pinch Injury: Evidence of Behavioral Studies and Bax Protein Expression.CNS Neurol Disord Drug Targets. 2019;18(10):791-797.
3.Xiang Q, Xian-Hui Li（通訊）, Fang XX, Jia J, Ren J, Dong YC, Ou-Yang C.Alterations of synaptic plasticity in aged rats: Evidence of functional and morphological studies.Technol Health Care. 2018;26(2):271-278.
4.Xiang Q,Xian-Hui Li（通訊）, Yang B, Fang XX, Jia J, Ren J, Dong YC, Ou-Yang C, Wang GC.Allicin attenuates tunicamycin-induced cognitive deficits in rats via its synaptic plasticity regulatory activity.Iran J Basic Med Sci. 2017 Jun;20(6):676-682.
5.Zhu YF,Xian-Hui Li（通訊）, Yuan ZP, Li CY, Tian RB, Jia W, Xiao ZP.Allicin improves endoplasmic reticulum stress-related cognitive deficits via PERK/Nrf2 antioxidative signaling pathway.Eur J Pharmacol. 2015 Sep 5;762:239-46.
6.Xiang Q, Yu C, Zhu YF, Li CY, Tian RB,Xian-Hui Li（通訊）.Nuclear factor erythroid 2-related factor 2 antibody attenuates thermal hyperalgesia in the dorsal root ganglion: Neurochemical changes and behavioral studies after sciatic nerve-pinch injury.Injury. 2016 Aug;47(8):1647-54.
7.Xiang Q, Zhang J, Li CY, Wang Y, Zeng MJ, Cai ZX, Tian RB, Jia W,Xian-Hui Li（通訊）Insulin resistance-induced hyperglycemia decreased the activation of Akt/CREB in hippocampus neurons: Molecular evidence for mechanism of diabetes-induced cognitive dysfunction.Neuropeptides. 2015 Dec;54:9-15.
8.Xian-Hui Li, Xin X, Wang Y, Wu JZ, Jin ZD, Ma LN, Nie CJ, Xiao X, Hu Y, Jin MW. Pentamethylquercetin protects against diabetes-related cognitive deficits in diabetic Goto-Kakizaki rats.J Alzheimers Dis. 2013;34(3):755-67.
9.Xian-Hui Li, Li CY, Lu JM, Tian RB, Wei J.Allicin ameliorates cognitive deficits ageing-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathways.Neurosci Lett. 2012 Apr 11;514(1):46-50.
10.Xian-Hui Li, Li CY, Xiang ZG, Hu JJ, Lu JM, Tian RB, Jia W.Allicin ameliorates cardiac hypertrophy and fibrosis through enhancing of Nrf2 antioxidant signaling pathways.Cardiovasc Drugs Ther. 2012 Dec;26(6):457-65.
