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張永昌導師簡介

基本信息

張永昌,男,1985年6月生,醫學博士,副主任醫師,碩士生導師,湖南省腫瘤醫院肺胃腸内科副主任、湖南省呼吸腫瘤臨床醫學研究中心副主任。

人才榮譽及學術任職

國家優青,湖南省科技創新領軍人才,第十一屆湖南省青年科學家獎;中華醫學會青年科技獎,湖南省青年五四獎章,湖南省委組織部“湖湘青年英才”,湖南省人才托舉工程“年輕優秀科技人才”,湖南省“225”人才工程優秀科技人才,長沙市第五屆“十大傑出青年”,CSCO Young委員/PICOS Young主任委員,湖南省醫學會腫瘤内科專委會青委會委員,中國抗癌協會腫瘤呼吸病學專委會委員,中國抗癌協會腫瘤精準治療專委會委員

研究方向

(1)早期肺癌精準診斷及治療後複發監測;圍繞早期肺癌的臨床診斷,開發出基于液體活檢及影像組學的高靈敏度及特異性的診療手段并開展臨床隊列驗證;(2)肺癌靶向及免疫治療耐藥機制及幹預策略研究;圍繞肺癌靶向及免疫治療耐藥的基本原理,探讨其深層次的分子機制的轉化研究并制定耐藥後臨床解決方案;(3)肺癌定向器官轉移的分子機制及臨床診治;圍繞肺癌腦轉移等特定器官轉移的發生機制、分子特征等相關領域開展基礎及臨床轉化研究,解決診療難題。

聯系方式:zhangyongchang@csu.edu.cn

近3年代表性學術成果

序号

論文(專著)

名稱/刊名/作者

年卷頁碼(xx年xx卷xx頁)

發表(出版)時間(年月日)

他引總次數

檢索數據庫

1

Detection of Nonreciprocal/Reciprocal ALK Translocation as Poor Predictive Marker in Patients With First-Line Crizotinib-Treated ALK-Rearranged NSCLC. Journal of thoracic oncology.Zhang, Y., Zeng, L., Zhou, C., Li, Y., Wu, L., Xia, C., Jiang, W., Hu, Y., Liao, D., Xiao, L., Liu, L., Yang, H., Xiong, Y., Guan, R., Lizaso, A., Mansfield, A. S., & Yang, N. (2020).共同第一作者排第一(1/5), PMID: 32112982

Journal of thoracic oncology: 15(6), 1027–1036.

2020 Jun.

Journal Impact Factor (2021): 20.121

35

Web of Science

2

Efficacy and Safety of Apatinib Plus Vinorelbine in Patients With Wild-Type Advanced Non-Small Cell Lung Cancer After Second-Line Treatment Failure: A Nonrandomized Clinical Trial. JAMA network open. Zhang, X., Xiong, Y., Xia, Q., Wu, F., Liu, L., Zhou, Y., Zeng, L., Zhou, C., Xia, C., Jiang, W., Liao, D., Xiao, L., Liu, L., Yang, H., Guan, R., Li, K., Wang, J., Lei, G.,Zhang, Y., & Yang, N. (2020).通訊作者(1/1), PMID: 32191330

JAMA network open, 3(3), e201226.

2020 Dec.

Journal Impact Factor (2021): 13.353

12

Web of Science

3

Clinical impact of uncommon epidermal growth factor receptor exon 19 insertion-deletion variants on epidermal growth factor receptor-tyrosine kinase inhibitor efficacy in non-small-cell lung cancer. European journal of cancer. Peng, X., Long, X., Liu, L., Zeng, L., Yang, H., Jiang, W., Liao, D., Li, K., Wang, J., Lizaso, A., Mao, X., Xu, Q., Mansfield, A. S., Yang, N., &Zhang, Y. (2020).通訊作者(1/2), PMID: 33171317

European journal of cancer (Oxford, England : 1990), 141, 199–208.

2019 Apr.

Journal Impact Factor (2021): 10.022

8

Web of Science

4

Association Between Sex and Immune-Related Adverse Events During Immune Checkpoint Inhibitor Therapy. Journal of the National Cancer Institute, Jing, Y.,Zhang, Y., Wang, J., Li, K., Chen, X., Heng, J., Gao, Q., Ye, Y., Zhang, Z., Liu, Y., Lou, Y., Lin, S. H., Diao, L., Liu, H., Chen, X., Mills, G. B., & Han, L. (2021).共同第一作者排第二(2/4), PMID: 33705549

Journal of the National Cancer Institute, 113(10), 1396–1404.

2021 Oct 1.

Journal Impact Factor (2021): 11.816

9

Web of Science

5

Profiling of immune features to predict immunotherapy efficacy. Innovation (New York, N.Y.). Ye, Y.,Zhang, Y., Yang, N., Gao, Q., Ding, X., Kuang, X., Bao, R., Zhang, Z., Sun, C., Zhou, B., Wang, L., Hu, Q., Lin, C., Gao, J., Lou, Y., Lin, S. H., Diao, L., Liu, H., Chen, X., Mills, G. B., … Han, L. (2021).共同第一作者排第二(2/4), PMID: 34977836

Innovation (New York, N.Y.), 3(1), 100194.

2021 Dec 2, Journal Impact Factor (2021): 28.506

7

Web of Science

6

Disease progression patterns and molecular resistance mechanisms to crizotinib of lung adenocarcinoma harboring ROS1 rearrangements.Zhang, Y., Huang, Z., Zeng, L., Zhang, X., Li, Y., Xu, Q., Yang, H., Lizaso, A., Xu, C., Liu, J., Wang, W., Song, Z., Ou, S. I., & Yang, N. (2022).共同第一作者排第1(1/3), 共同通訊排第二(2/2), PMID: 35361870

NPJ precision oncology, 6(1), 20.

2022 Mar 31, Journal Impact Factor (2021): 10.092

3

Web of Science

7

Clinical and molecular feature-based nomogram model for predicting benefit from bevacizumab combined with first-generation EGFR-tyrosine kinase inhibitor (TKI) in EGFR-mutant advanced NSCLC. Zhang, Y., Zhang, X., Zhang, R., Xu, Q., Yang, H., Lizaso, A., Xu, C., Liu, J., Wang, W., Ou, S. I., Zhang, J., Song, Z., & Yang, N. (2021). 共同第一作者排第1(1/3), 共同通訊排第二(2/2), PMID: 34663309

BMC medicine, 19(1):245

2021 Oct 19, Journal Impact Factor (2021): 11.150

5

Web of Science

8

Clinical and molecular factors that impact the efficacy of first-line crizotinib in ROS1-rearranged non-small-cell lung cancer: a large multicenter retrospective study.Zhang, Y., Zhang, X., Zhang, R., Xu, Q., Yang, H., Lizaso, A., Xu, C., Liu, J., Wang, W., Ou, S. I., Zhang, J., Song, Z., & Yang, N. (2021).共同第一作者排第1(1/3), 共同通訊排第二(2/2), PMID: 34511132

BMC medicine, 19(1), 206.

2021 Sep 13, Journal Impact Factor (2021): 11.150

5

Web of Science

 

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